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Article

C/EBPα dysregulation in AML and ALL.

Critical reviews in oncogenesis - 1 Jan 2011

Paz-Priel Ido, Friedman Alan

Abstract excerpt

The transcription factor CCAAT/enhancer binding protein a (C/EBPα) is a critical regulator of myeloid development, directing granulocyte, and monocyte differentiation. As such, it is dysregulated in more than half of patients with acute myeloid leukemia (AML). C/EBPα expression is suppressed as result of common leukemia-associated genetic and epigenetic alterations such as AML1-ETO, BCR-ABL, FLT3-ITD, or CEBPA...

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Topics

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Share to CCAAT-Enhancer-Binding Protein-alpha
Share to Cell Transformation, Neoplastic
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Hematopoiesis

Share to Leukemia, Myeloid, Acute

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 22150310
DOI: 10.1615/critrevoncog.v16.i1-2.90
PMCID: PMC3243939

Genes

BCR
EBP
FLT3

Provenance

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