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Article

Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML.

Leukemia - 1 Sept 2021

Heyes Elizabeth, Schmidt Luisa, Manhart Gabriele, Eder Thomas, Proietti Ludovica, Grebien Florian

Abstract excerpt

Mutations in the gene encoding the transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) occur in 10-15% of acute myeloid leukemia (AML). Frameshifts in the CEBPA N-terminus resulting in exclusive expression of a truncated p30 isoform represent the most prevalent type of CEBPA mutations in AML. C/EBPα p30 interacts with the epigenetic machinery, but it is incompletely understood how p30-induced...

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Identifiers

PMID: 33623142
DOI: 10.1038/s41375-021-01169-6
PMCID: PMC7611617

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