Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia

4 Jul 2014

Abstract excerpt

The transcription factor Sox4 plays an indispensable role in the development of early progenitor B cells from hematopoietic stem cells. However, its role in B-cell acute lymphoblastic leukemia, a malignant counterpart of normal progenitor B cells, is not fully understood. Here we show that SOX4 is highly expressed in human acute lymphoblastic leukemia cells. To systematically study the function of Sox4 in acute...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24997151
DOI: 10.3324/haematol.2014.104695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemiaPMID 24997151Read ↗

SOX4 enables oncogenic survival signals in acute lymphoblastic leukemiaSemantic proximity Read ↗

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.Semantic proximity Read ↗

SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignanciesSemantic proximity Read ↗

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafishSemantic proximity Read ↗

SOX6 blocks the proliferation of BCR-ABL1+ and JAK2V617F+ leukemic cellsSemantic proximity Read ↗

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic miceSemantic proximity Read ↗

SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axisSemantic proximity Read ↗

The Role of Stem Cell Factor SALL4 in LeukemogenesisSemantic proximity Read ↗

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphomaSemantic proximity Read ↗

Highly specific overexpression of the transcription factor SOX11 in human malignant gliomasSemantic proximity Read ↗

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.