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Article

Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.

Cytokine - 1 Jan 2014

Matteini A M, Li J, Lange E M, Tanaka T, Lange L A, Tracy R P, Wang Y, Biggs M L, Arking D E, Fallin M D, Chakravarti A, Psaty B M, Bandinelli S, Ferrucci L, Reiner A P, Walston J D

Abstract excerpt

Activation of inflammatory pathways measured by serum inflammatory markers such as interleukin-18 (IL-18) and interleukin-1 receptor antagonist (IL-1ra) is strongly associated with the progression of chronic disease states in older adults. Given that these serum cytokine levels are in part a heritable trait, genetic variation may predict increased serum levels. Using the Cardiovascular Health Study and InCHIANTI...

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Identifiers

PMID: 24182552
DOI: 10.1016/j.cyto.2013.10.002
PMCID: PMC4060632

Genes

NLRC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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