The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.

doi:10.4049/jimmunol.1302727

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Article

The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2014

Hedl Matija, Zheng Shasha, Abraham Clara

Abstract excerpt

Fine-tuning of cytokine-inducing pathways is essential for immune homeostasis. Consistently, a dysregulated increase or decrease in pattern-recognition receptor (PRR)-induced signaling and cytokine secretion can lead to inflammatory bowel disease. Multiple gene loci are associated with inflammatory bowel disease, but their functional effects are largely unknown. One such region in chromosome 2q12 (rs917997), also...

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PMID: 24842757
DOI: 10.4049/jimmunol.1302727
PMCID: PMC4146459

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