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Article

An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2007

Frayling Timothy M, Rafiq Sajjad, Murray Anna, Hurst Alison J, Weedon Michael N, Henley William, Bandinelli Stefania, Corsi Anna-Maria, Ferrucci Luigi, Guralnik Jack M, Wallace Robert B, Melzer David

Abstract excerpt

BACKGROUND: The proinflammatory cytokine interleukin-18 (IL-18) is associated with major disabling conditions, although whether as byproduct or driver is unclear. The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown. METHODS: We used 1671 participants aged 65-80 years from two studies: the InCHIANTI study and wave 6 of the Iowa-Established Populations for...

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Identifiers

PMID: 17301041
DOI: 10.1093/gerona/62.1.73
PMCID: PMC2669299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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