Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans.

doi:10.1007/s00251-011-0596-7

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Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans.

Immunogenetics - 1 May 2012

Tekola Ayele Fasil, Doumatey Ayo, Huang Hanxia, Zhou Jie, Charles Bashira, Erdos Michael, Adeleye Jokotade, Balogun Williams, Fasanmade Olufemi, Johnson Thomas, Oli Johnnie, Okafor Godfrey, Amoah Albert, Eghan Benjamin A, Agyenim-Boateng Kofi, Acheampong Joseph, Adebamowo Clement A, Herbert Alan, Gerry Norman, Christman Michael, Chen Guanjie, Shriner Daniel, Adeyemo Adebowale, Rotimi Charles N

Abstract excerpt

Interleukins (ILs) are key mediators of the immune response and inflammatory process. Plasma levels of IL-10, IL-1Ra, and IL-6 are associated with metabolic conditions, show large inter-individual variations, and are under strong genetic control. Therefore, elucidation of the genetic variants that influence levels of these ILs provides useful insights into mechanisms of immune response and pathogenesis of...

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PMID: 22205395
DOI: 10.1007/s00251-011-0596-7
PMCID: PMC3418332

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PMS1
YWHAZ

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