NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients With Acute Coronary Syndromes: Genome-Wide Association Study in the PLATelet inhibition and patient Outcomes Trial (PLATO).

doi:10.1161/CIRCGENETICS.114.000724

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Article

NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients With Acute Coronary Syndromes: Genome-Wide Association Study in the PLATelet inhibition and patient Outcomes Trial (PLATO).

Circulation. Cardiovascular genetics - 1 Jun 2015

Johansson Åsa, Eriksson Niclas, Becker Richard C, Storey Robert F, Himmelmann Anders, Hagström Emil, Varenhorst Christoph, Axelsson Tomas, Barratt Bryan J, James Stefan K, Katus Hugo A, Steg Philippe Gabriel, Syvänen Ann-Christine, Wallentin Lars, Siegbahn Agneta

Abstract excerpt

BACKGROUND: Interleukin 18 (IL-18) promotes atherosclerotic plaque formation and is increased in patients with acute coronary syndromes. However the relative contribution of genetic variants to the IL-18 levels has not been fully determined. METHODS AND RESULTS: Baseline plasma IL-18 levels were measured in 16 633 patients with acute coronary syndrome, of whom 9340 had genetic data that passed genotype quality...

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Identifiers

PMID: 25747584
DOI: 10.1161/CIRCGENETICS.114.000724

Genes

NLRC4
CARD16
CARD18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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