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Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study

2024-07-03

Abstract excerpt

<h4>Background</h4> Inflammation is an emerging target for the prevention and treatment of cardiovascular disease (CVD). This drug-target Mendelian randomization (MR) study aimed to predict the on-target effects of IL-18 inhibition on CVD risk. Furthermore, we aimed to explore the effects of IL-18 inhibition on cardio-metabolic traits, cardiac structure, and function, and identify potential adverse outcomes. <h4>M...

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Literature Corpus work
a1fa3358-3dcd-5441-ac5b-c93821eb9a70
DOI
10.1101/2024.07.01.24309808
Open publication

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Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization StudyDOI 10.1101/2024.07.01.24309808
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