Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.

doi:10.1161/CIRCGENETICS.115.001079

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Article

Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.

Circulation. Cardiovascular genetics - 1 Oct 2015

Zeller Tanja, Haase Tina, Müller Christian, Riess Helene, Lau Denise, Zeller Simon, Krause Jasmin, Baumert Jens, Pless Ole, Dupuis Josée, Wild Philipp S, Eleftheriadis Medea, Waldenberger Melanie, Zeilinger Sonja, Ziegler Andreas, Peters Annette, Tiret Laurence, Proust Carole, Marzi Carola, Munzel Thomas, Strauch Konstantin, Prokisch Holger, Lackner Karl J, Herder Christian, Thorand Barbara, Benjamin Emilia J, Blankenberg Stefan, Koenig Wolfgang, Schnabel Renate B

Abstract excerpt

BACKGROUND: Interleukin-18 (IL-18) is a pleiotropic cytokine centrally involved in the cytokine cascade with complex immunomodulatory functions in innate and acquired immunity. Circulating IL-18 concentrations are associated with type 2 diabetes mellitus, cardiovascular events, and diverse inflammatory and autoimmune disorders. METHODS AND RESULTS: To identify causal variants affecting circulating IL-18...

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Identifiers

PMID: 26362438
DOI: 10.1161/CIRCGENETICS.115.001079
PMCID: PMC4618032

Genes

NLRC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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