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Article

Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women's health initiative.

European journal of preventive cardiology - 18 Feb 2026

Wissel Stephanie, Hovey Kathleen M, Andrews Chris A, Miller Connor R, Shadyab Aladdin H, Wallace Robert B, Jung Su Yon, Nassir Rami, Eaton Charles, Stefanick Marcia L, LaCroix Andrea, Manson JoAnn E, Wassertheil-Smoller Sylvia, LaMonte Michael J, Haring Bernhard

Abstract excerpt

AIMS: Interleukin-6 (IL-6) levels have been related to increased risk of chronic disease and mortality. Whether genetic IL-6 receptor (IL6R) blockade is associated with lower chronic disease risk or greater longevity is unknown. METHODS AND RESULTS: The analytic cohort consisted of 38 807 Women's Health Initiative participants who had available genotyping information, of which 23 464 were eligible to survive to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40674461
DOI: 10.1093/eurjpc/zwaf444

Genes

IL6R

Variants

rs8192284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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