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Article

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.

Genes and immunity - 1 Jun 2007

Rafiq S, Stevens K, Hurst A J, Murray A, Henley W, Weedon M N, Bandinelli S, Corsi A M, Guralnik J M, Ferruci L, Melzer D, Frayling T M

Abstract excerpt

Interleukin-1-receptor antagonist (IL-1RA) modulates the biological activity of the proinflammatory cytokine interleukin-1 (IL-1) and could play an important role in the pathophysiology of inflammatory and metabolic traits. We genotyped seven single nucleotide polymorphisms (SNPs) that capture a large proportion of common genetic variation in the IL-1RN gene in 1256 participants from the Invecchiare in Chianti...

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PMID: 17443229
DOI: 10.1038/sj.gene.6364393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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