Article
Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections.
Genes and immunity - 1 Mar 2017
Vergara C, Thio C, Latanich R, Cox A L, Kirk G D, Mehta S H, Busch M, Murphy E L, Villacres M C, Peters M G, French A L, Golub E, Eron J, Lahiri C D, Shrestha S, Gustafson D, Young M, Anastos K, Aouizerat B, Kim A Y, Lauer G, Thomas D L, Duggal P
Abstract excerpt
Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are associated with elevated IL-18, suggesting inflammasome activation. However, there is marked person-to-person variation in the inflammasome response to HCV and HIV....
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