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Understanding the X chromosome inactivation cycle in mice

29 Oct 2013

Abstract excerpt

During mouse development, imprinted X chromosome inactivation (XCI) is observed in preimplantation embryos and is inherited to the placental lineage, whereas random XCI is initiated in the embryonic proper. Xist RNA, which triggers XCI, is expressed ectopically in cloned embryos produced by somatic cell nuclear transfer (SCNT). To understand these mechanisms, we undertook a large-scale nuclear transfer study...

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PMID: 24172050
DOI: 10.4161/epi.26939

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