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Article

RNAi-mediated knockdown of <i>Xist</i> can rescue the impaired postimplantation development of cloned mouse embryos

7 Nov 2011

Abstract excerpt

Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here we identify the most upstream level of dysfunction leading to impaired development of clones by using RNAi against Xist, a gene responsible for X chromosome inactivation...

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PMID: 22065773
DOI: 10.1073/pnas.1112664108

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