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Article

Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization

7 Mar 2016

Abstract excerpt

Dynamic epigenetic reprogramming occurs during normal embryonic development at the preimplantation stage. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term consequences. Among these, the skewed sex ratio, an indicator of reproductive hazards, was reported in bovine and...

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PMID: 26951653
DOI: 10.1073/pnas.1523538113

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