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Article

Epigenetic remodeling in preimplantation embryos: cows are not big mice

1 Jan 2018

Abstract excerpt

Epigenetic mechanisms allow the establishment and maintenance of multiple cellular phenotypes from a single genomic code. At the initiation of development, the oocyte and spermatozoa provide their fully differentiated chromatin that soon after fertilization undergo extensive remodeling, resulting in a totipotent state that can then drive cellular differentiation towards all cell types. These remodeling involves...

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PMID: 34178143
DOI: 10.21451/1984-3143-ar2018-0068

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