Article
Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease.
Cognitive neuroscience - 1 Jan 2013
Pettigrew Corinne, Soldan Anja, Li Shanshan, Lu Yi, Wang Mei-Cheng, Selnes Ola A, Moghekar Abhay, O'Brien Richard, Albert Marilyn, The Biocard Research Team
Abstract excerpt
The APOE ε4 allele increases the risk of developing Alzheimer's disease, whereas the APOE ε2 allele reduces risk. We examined whether cognitive reserve (CR), as measured by an index consisting of education, reading, and vocabulary, modifies these associations. CR was measured at baseline in 257 cognitively normal individuals (mean age 57.2 years) who have been followed for up to 17 years (mean follow-up = 9.2...
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