Association between apolipoprotein E ε4 and longitudinal cognitive decline: nested case-control study among chinese community-dwelling elders.

doi:10.1159/000324991

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Article

Association between apolipoprotein E ε4 and longitudinal cognitive decline: nested case-control study among chinese community-dwelling elders.

Neuropsychobiology - 1 Jan 2011

Ma Fei, Wang Jianhua, Miao Rujuan, Zhao Wei, Wang Qian

Abstract excerpt

BACKGROUND/AIMS: Cognitive decline in the elderly is an early predictor of dementia. The apolipoprotein E (APOE) ε4 allele is considered an important genetic determinant of Alzheimer's disease (AD), and strongly suspected to play a role in cognitive variation. However, its effects upon predicting the progression of cognitive decline more generally remain unclear. Our aim was to explore the role of APOE ε4 in...

Topics

Aged
Aged, 80 and over
Apolipoprotein E4
Asian People
Case-Control Studies
Cognition Disorders
Cohort Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Geriatric Assessment

Humans

Male

Neuropsychological Tests

Odds Ratio

Residence Characteristics

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 21701228
DOI: 10.1159/000324991

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21701228-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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