Article
Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life.
Neurobiology of learning and memory - 1 Dec 2017
Sinclair Lindsey I, Pleydell-Pearce Christopher W, Day Ian N M
Abstract excerpt
BACKGROUND: ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. METHODS: We invited all...
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