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Article

The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

6 Jan 2017

Abstract excerpt

OBJECTIVES: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable. METHODS: Thirty-six...

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PMID: 28059047
DOI: 10.1017/s1355617716000990

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