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Article

Association of Early Life Risk Factors and APOE ε4 With Incident Dementia: Evidence From 14 Years of U.S. Data.

Journal of the American Geriatrics Society - 1 Nov 2025

Choi Eun Young, Cho Gawon, Chang Virginia W

Abstract excerpt

BACKGROUND: Early life is a critical period for brain development, laying the foundation for cognitive reserve. However, it remains unclear how various aspects of early life independently contribute to dementia risk, and whether these associations are modified by APOE ε4 genotype. PARTICIPANTS AND SETTING: We used data from the U.S. Health and Retirement Study (HRS), a nationally representative cohort of older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40947752
DOI: 10.1111/jgs.70086
PMCID: PMC12448107

Genes

APOE

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