Article
Do apolipoprotein E genotype and educational attainment predict the rate of cognitive decline in normal aging? A 12-year follow-up of the Maastricht Aging Study.
Neuropsychology - 1 Jul 2012
Van Gerven Pascal W M, Van Boxtel Martin P J, Ausems Eleonora E B, Bekers Otto, Jolles Jelle
Abstract excerpt
OBJECTIVE: We investigated suspected longitudinal interaction effects of apolipoprotein E (APOE) genotype and educational attainment on cognitive decline in normal aging. METHOD: Our sample consisted of 571 healthy, nondemented adults aged between 49 and 82 years. Linear mixed-models analyses were performed with four measurement time points: baseline, 3-year, 6-year, and 12-year follow-up. Covariates included age...
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