Article
The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan.
Molecular psychiatry - 1 Oct 2014
Felsky D, Szeszko P, Yu L, Honer W G, De Jager P L, Schneider J A, Malhotra A K, Lencz T, Ikuta T, Pipitone J, Chakravarty M M, Lobaugh N J, Mulsant B H, Pollock B G, Kennedy J L, Bennett D A, Voineskos A N
Abstract excerpt
Prior to intervention trials in individuals genetically at-risk for late-onset Alzheimer's disease, critical first steps are identifying where (neuroanatomic effects), when (timepoint in the lifespan) and how (gene expression and neuropathology) Alzheimer's risk genes impact the brain. We hypothesized that variants in the sortilin-like receptor (SORL1) gene would affect multiple Alzheimer's phenotypes before the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.