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Article

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.

Annals of neurology - 1 Jan 2011

Reitz Christiane, Tokuhiro Shinya, Clark Lorraine N, Conrad Christopher, Vonsattel Jean-Paul, Hazrati Lili-Naz, Palotás András, Lantigua Raphael, Medrano Martin, Z Jiménez-Velázquez Ivonne, Vardarajan Badri, Simkin Irene, Haines Jonathan L, Pericak-Vance Margaret A, Farrer Lindsay A, Lee Joseph H, Rogaeva Ekaterina, George-Hyslop Peter St, Mayeux Richard

Abstract excerpt

OBJECTIVE: Sorting mechanisms that cause the amyloid precursor protein (APP) and the β-secretases and γ-secretases to colocalize in the same compartment play an important role in the regulation of Aβ production in Alzheimer's disease (AD). We and others have reported that genetic variants in the Sortilin-related receptor (SORL1) increased the risk of AD, that SORL1 is involved in trafficking of APP, and that...

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Identifiers

PMID: 21280075
DOI: 10.1002/ana.22308
PMCID: PMC3086759

Genes

SORCS1
APP
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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