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Article

The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.

Current neurology and neuroscience reports - 1 Sept 2008

Lee Joseph H, Barral Sandra, Reitz Christiane

Abstract excerpt

Recent studies indicate that two clusters of single nucleotide polymorphisms in the neuronal sortilin-related receptor gene (SORL1) are causally associated with late-onset Alzheimer's disease (AD). At the cellular level, SORL1 is thought to be involved in intracellular trafficking of amyloid precursor protein. When this gene is suppressed, toxic amyloid beta production is increased, and high levels of amyloid...

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Source

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Identifiers

PMID: 18713574
DOI: 10.1007/s11910-008-0060-8
PMCID: PMC2694663

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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