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Article

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

4 Nov 2009

Abstract excerpt

BACKGROUND: Variations in sortilin-related receptor (SORL1) expression and function have been implicated in Alzheimers Disease (AD). Here, to gain insights into SORL1, we evaluated SORL1 expression and splicing as a function of AD and AD neuropathology, neural gene expression and a candidate single nucleotide polymorphism (SNP). RESULTS: To identify SORL1 splice variants, we scanned each of the 46 internal SORL1...

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PMID: 19889229
DOI: 10.1186/1750-1326-4-46

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