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Article

Association of SORL1 gene variants with hippocampal and cerebral atrophy and Alzheimer's disease.

Current Alzheimer research - 1 Jan 2014

Assareh Amelia A, Piguet Olivier, Lye Tanya C, Mather Karen A, Broe Gerald A, Schofield Peter R, Sachdev Perminder S, Kwok John B J

Abstract excerpt

BACKGROUND: Sortilin-related receptor, Sorl1, is a neuronal receptor that interacts with the amyloid precursor protein to regulate amyloidogenesis. Variants in the gene encoding Sorl1 are associated with Alzheimer's disease (AD), as well as its neuroimaging markers. OBJECTIVES: To investigate the relationship between SORL1 gene variants with ADrelated brain morphologies and AD, testing for sex-specific effects....

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Identifiers

PMID: 24938503
DOI: 10.2174/1567205011666140618101408

Genes

SORL1

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