Article
Sorl1 as an Alzheimer's disease predisposition gene?
Neuro-degenerative diseases - 1 Jan 2008
Webster Jennifer A, Myers Amanda J, Pearson John V, Craig David W, Hu-Lince Diane, Coon Keith D, Zismann Victoria L, Beach Thomas, Leung Doris, Bryden Leslie, Halperin Rebecca F, Marlowe Lauren, Kaleem Mona, Huentelman Matthew J, Joshipura Keta, Walker Douglas, Heward Christopher B, Ravid Rivka, Rogers Joseph, Papassotiropoulos Andreas, Hardy John, Reiman Eric M, Stephan Dietrich A
Abstract excerpt
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset...
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