Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.

Scientific reports - 21 Mar 2016

Huang Chu-Chung, Liu Mu-En, Kao Hung-Wen, Chou Kun-Hsien, Yang Albert C, Wang Ying-Hsiu, Chen Tong-Ru, Tsai Shih-Jen, Lin Ching-Po

Abstract excerpt

Sortilin receptor 1 (SORL1) is involved in cellular trafficking of amyloid precursor protein and plays an essential role in amyloid-beta peptide generation in Alzheimer disease (AD). The major A allele in a SORL1 single nucleotide polymorphism (SNP), rs3824968, is associated with an increased AD risk. However, the role of SORL1 rs3824968 in the normal ageing process has rarely been examined in relation to brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over
Share to Aging
Share to Alzheimer Disease
Share to Brain
Share to Gray Matter
Share to LDL-Receptor Related Proteins
Share to Magnetic Resonance Imaging
Share to Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26996954
DOI: 10.1038/srep23362
PMCID: PMC4800313

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.PMID 26996954Read ↗

SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.Semantic proximity Read ↗

Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults.Semantic proximity Read ↗

Impact of SORL1 genetic variations on MRI markers in non-demented elders.Semantic proximity Read ↗

Endophenotypic Effects of the SORL1 Variant rs2298813 on Regional Brain Volume in Patients with Alzheimer’s DiseaseSemantic proximity Read ↗

Association of SORL1 gene variants with hippocampal and cerebral atrophy and Alzheimer's disease.Semantic proximity Read ↗

Sex moderates the effects of the Sorl1 gene rs2070045 polymorphism on cognitive impairment and disruption of the cingulum integrity in healthy elderly.Semantic proximity Read ↗

The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan.Semantic proximity Read ↗

Association of SORL1 polymorphisms and SORL1-APOE ε4 interaction with risk of subjective cognitive decline and mild cognitive impairment in the Chinese population.Semantic proximity Read ↗

SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan.Semantic proximity Read ↗

Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults.Semantic proximity Read ↗

Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.Semantic proximity Read ↗

Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.