Article
The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors.
Haematologica - 1 Apr 2014
Liss Adam, Ooi Chia-Huey, Zjablovskaja Polina, Benoukraf Touati, Radomska Hanna S, Ju Chen, Wu Mengchu, Balastik Martin, Delwel Ruud, Brdicka Tomas, Tan Patrick, Tenen Daniel G, Alberich-Jorda Meritxell
Abstract excerpt
C/EPBα proteins, encoded by the CCAAT-enhancer-binding protein α gene, play a crucial role in granulocytic development, and defects in this transcription factor have been reported in acute myeloid leukemia. Here, we defined the C/EBPα signature characterized by a set of genes up-regulated upon C/EBPα activation. We analyzed expression of the C/EBPα signature in a cohort of 525 patients with acute myeloid leukemia...
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