Article
Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.
Haematologica - 1 Mar 2011
Hollink Iris H I M, van den Heuvel-Eibrink Marry M, Arentsen-Peters Susan T C J M, Zimmermann Martin, Peeters Justine K, Valk Peter J M, Balgobind Brian V, Sonneveld Edwin, Kaspers Gertjan J L, de Bont Eveline S J M, Trka Jan, Baruchel Andre, Creutzig Ursula, Pieters Rob, Reinhardt Dirk, Zwaan C Michel
Abstract excerpt
BACKGROUND: Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated with a favorable outcome, but this may be restricted to the case of double mutations in CEBPA in adult acute myeloid leukemia. In pediatric acute myeloid...
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