Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.

Leukemia - 1 Jan 2023

Adamo Assunta, Chin Paulynn, Keane Peter, Assi Salam A, Potluri Sandeep, Kellaway Sophie G, Coleman Daniel, Ames Luke, Ptasinska Anetta, Delwel H Ruud, Cockerill Peter N, Bonifer Constanze

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by mutations in genes encoding transcriptional and epigenetic regulators together with signaling genes. It is characterized by a disturbance of differentiation and abnormal proliferation of hematopoietic progenitors. We have previously shown that each AML subtype establishes its own core gene regulatory network (GRN), consisting of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to CCAAT-Enhancer-Binding Protein-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Proteins

Share to Cell Differentiation

Share to Gene Regulatory Networks

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Protein Degradation and Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 36333583
DOI: 10.1038/s41375-022-01744-5
PMCID: PMC9883165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.PMID 36333583Read ↗

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.Semantic proximity Read ↗

Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML.Semantic proximity Read ↗

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPASemantic proximity Read ↗

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.Semantic proximity Read ↗

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity.Semantic proximity Read ↗

CEBPA-double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features.Semantic proximity Read ↗

Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia.Semantic proximity Read ↗

C/EBPα dysregulation in AML and ALL.Semantic proximity Read ↗

<i>TET2</i> lesions enhance the aggressiveness of <i>CEBPA-</i> mutant AML by rebalancing <i>GATA2</i> expressionSemantic proximity Read ↗

Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AMLSemantic proximity Read ↗

Distinct gene regulatory networks govern hematopoietic and leukemia stem cellsSemantic proximity Read ↗

Detection of CEBPA double mutants in acute myeloid leukemia using a custom gene expression array.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.