Article
Correlation of C/EBPα expression with response and resistance to imatinib in chronic myeloid leukaemia.
Japanese journal of clinical oncology - 1 Aug 2015
Kagita Sailaja, Uppalapati Srihari, Gundeti Sadasivudu, Digumarti Raghunadharao
Abstract excerpt
OBJECTIVE: Altered differentiation is a common feature of haematopoietic malignancies with poor prognosis. CAAT/enhancer binding protein alpha (C/EBPα) is a key transcription factor that regulates myeloid differentiation. This study is aimed to know the prognostic value of CAAT/enhancer binding protein alpha expression and correlate its expression with response to imatinib therapy. METHODS: We quantified the...
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