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Article

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia

19 Nov 2012

Abstract excerpt

C/EBPs are a family of transcription factors that regulate growth control and differentiation of various tissues. We found that C/EBPγ is highly upregulated in a subset of acute myeloid leukemia (AML) samples characterized by C/EBPα hypermethylation/silencing. Similarly, C/EBPγ was upregulated in murine hematopoietic stem/progenitor cells lacking C/EBPα, as C/EBPα mediates C/EBPγ suppression. Studies in myeloid...

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PMID: 23160200
DOI: 10.1172/jci65102

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