Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

1 May 2008

Abstract excerpt

Functional loss of CCAAT/enhancer binding protein alpha (C/EBP alpha), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here, we show the effect of epigenetic aberrations in regulating C/EBP alpha expression in acute myeloid leukemia (AML). Comprehensive DNA methylation analyses of the CpG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18451139
DOI: 10.1158/0008-5472.can-08-0483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid LeukemiaPMID 18451139Read ↗

Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review)Semantic proximity Read ↗

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.Semantic proximity Read ↗

A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.Semantic proximity Read ↗

Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML.Semantic proximity Read ↗

C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations.Semantic proximity Read ↗

[Roles of CEBPA mutation and expression abnormality in acute myeloid leukemia - review].Semantic proximity Read ↗

C/EBPα dysregulation in AML and ALL.Semantic proximity Read ↗

The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemiaSemantic proximity Read ↗

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemiaSemantic proximity Read ↗

C/EBPα deregulation as a paradigm for leukemogenesis.Semantic proximity Read ↗

C/EBPα in normal and malignant myelopoiesis.Semantic proximity Read ↗

The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.