Article
In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages.
Biological & pharmaceutical bulletin - 1 Jan 2014
Kono Yusuke, Kawakami Shigeru, Higuchi Yuriko, Yamashita Fumiyoshi, Hashida Mitsuru
Abstract excerpt
Tumor-associated macrophages (TAMs) have an alternatively activated macrophage phenotype (M2) and promote cancer cell proliferation, angiogenesis and metastasis. Nuclear factor-kappaB (NF-κB) is one of the master regulators of macrophage polarization. Here, we investigated the effect of inhibition of NF-κB activity by small interfering RNA (siRNA) on the pro-tumor response of macrophages located in the tumor...
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