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Article

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype.

Oncotarget - 9 Aug 2016

Zhang Fan, Wang Hongsheng, Wang Xianfeng, Jiang Guanmin, Liu Hao, Zhang Ge, Wang Hao, Fang Rui, Bu Xianzhang, Cai Shaohui, Du Jun

Abstract excerpt

Tumor-associated macrophages (TAMs) are a major component of leukocytic infiltrate in tumors, which facilitates tumor progression and promotes inflammation. TGF-β promotes the differentiation of non-activated macrophages into a TAM-like (M2-like) phenotype; however, the underlying mechanisms are not clear. In this study, we found that TGF-β induces a M2-like phenotype characterized by up-regulation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27418133
DOI: 10.18632/oncotarget.10561
PMCID: PMC5239552

Genes

SMAD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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