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Article

Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway.

Cells - 10 Apr 2020

Lin Yi-Hsuan, Wang Yi-Hsun, Peng Yi-Jen, Liu Feng-Cheng, Lin Gu-Jiun, Huang Shing-Hwa, Sytwu Huey-Kang, Cheng Chia-Pi

Abstract excerpt

Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA have not been elucidated. In the present work, we evaluated the effects and the mechanisms of IL-26 on M1 and M2 macrophage differentiation. Human or mouse macrophage cells were treated with lipopolysaccharides (LPS), interferon gamma...

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Identifiers

PMID: 32290250
DOI: 10.3390/cells9040938
PMCID: PMC7227026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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