Article

TGF-β type I receptor inhibitor suppresses polarization of tumor-associated macrophages to the M2 phenotype and exerts antitumor effects on colorectal cancer

2023-04-25

Abstract excerpt

<h4>Background: </h4> Macrophages can be classified into two main types based on their functions: pro-inflammatory M1-like and anti-inflammatory M2-like. Tumor-associated macrophages (TAMs) are macrophages that infiltrate tumor tissues and many TAM polarized to the M2 phenotype. M2-TAMs promote tumor progression through various mechanisms. Transforming growth factor (TGF)-β, which is abundant in tumor tissues and...

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Literature Corpus work: 229aa66f-2fae-5bb1-bc3b-e7fd9192d2e0
DOI: 10.21203/rs.3.rs-2815318/v1

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