Article
"Re-educating" tumor-associated macrophages by targeting NF-kappaB.
The Journal of experimental medicine - 9 Jun 2008
Hagemann Thorsten, Lawrence Toby, McNeish Iain, Charles Kellie A, Kulbe Hagen, Thompson Richard G, Robinson Stephen C, Balkwill Frances R
Abstract excerpt
The nuclear factor kappaB (NF-kappaB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-kappaB in cancer in maintaining the immunosuppressive phenotype of tumor-associated macrophages (TAMs). We show that macrophages are polarized via interleukin (IL)-1R and MyD88 to an immunosuppressive "alternative" phenotype that requires IkappaB kinase...
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