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Article

Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.

PloS one - 1 Jan 2014

Hernández Carlos, Barrachina María Dolores, Cosín-Roger Jesús, Ortiz-Masiá Dolores, Álvarez Ángeles, Terrádez Liria, Nicolau María Jesús, Alós Rafael, Esplugues Juan Vicente, Calatayud Sara

Abstract excerpt

Macrophage infiltration is a negative prognostic factor for most cancers but gastrointestinal tumors seem to be an exception. The effect of macrophages on cancer progression depends on their phenotype, which may vary between M1 (pro-inflammatory, defensive) to M2 (tolerogenic, pro-tumoral). Gastr...

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Identifiers

PMID: 24901518
DOI: 10.1371/journal.pone.0098458
PMCID: PMC4047028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24901518-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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