Article
COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps.
Carcinogenesis - 1 Sept 2011
Nakanishi Yuki, Nakatsuji Masato, Seno Hiroshi, Ishizu Shoko, Akitake-Kawano Reiko, Kanda Keitaro, Ueo Taro, Komekado Hideyuki, Kawada Mayumi, Minami Manabu, Chiba Tsutomu
Abstract excerpt
Macrophages are a major component of tumor stroma. Tumor-associated macrophages (TAMs) show anti- (M1) or protumor (M2) functions depending on the cytokine milieu of the tumor microenvironment. Cyclooxygenase-2 (COX-2) is constitutively expressed in a variety of tumors including colorectal cancer. TAMs are known to be a major source of COX-2 in human and mice intestinal tumors. COX-2 inhibitor reduces the number...
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