Article
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Frontiers in immunology - 1 Jan 2020
Suarez-Lopez Lucia, Kong Yi Wen, Sriram Ganapathy, Patterson Jesse C, Rosenberg Samantha, Morandell Sandra, Haigis Kevin M, Yaffe Michael B
Abstract excerpt
Chronic inflammation increases the risk for colorectal cancer through a variety of mechanisms involving the tumor microenvironment. MAPK-activated protein kinase 2 (MK2), a major effector of the p38 MAPK stress and DNA damage response signaling pathway, and a critical regulator of pro-inflammatory cytokine production, has been identified as a key contributor to colon tumorigenesis under conditions of chronic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.