Article
Curcumin Reprograms TAMs from a Protumor Phenotype towards an Antitumor Phenotype via Inhibiting MAO-A/STAT6 Pathway.
Cells - 2 Nov 2022
Jiang Mingjing, Qi Ying, Huang Wei, Lin Ying, Li Bo
Abstract excerpt
M1 phenotype macrophages have anticancer characteristics, whereas M2 phenotype macrophages promote tumor growth and metastasis. A higher M1/M2 ratio, therefore, has a beneficial effect on the tumor immune microenvironment, thereby inhibiting tumor growth. The natural alkaloid curcumin is found to have anticancer properties. However, the mechanism remains unclear. In this study, a cell co-culture system and M2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.