Article
Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.
PloS one - 1 Jan 2014
Nishikawa Kenichiro, Seo Naohiro, Torii Mie, Ma Nei, Muraoka Daisuke, Tawara Isao, Masuya Masahiro, Tanaka Kyosuke, Takei Yoshiyuki, Shiku Hiroshi, Katayama Naoyuki, Kato Takuma
Abstract excerpt
Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune cells and is generally implicated in inflammatory and autoimmune diseases. Although IL-17 as well as their source, mainly but not limited to Th17 cells, is also abundant in the inflamed intestine, the role of IL-17 in inflammatory bowel disease remains controversial. In the present study, by using IL-17 knockout (KO) mice, we...
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