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Article

The SWI/SNF complex in cancer - biology, biomarkers and therapy.

Nature reviews. Clinical oncology - 1 Jul 2020

Mittal Priya, Roberts Charles W M

Abstract excerpt

Cancer genome-sequencing studies have revealed a remarkably high prevalence of mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes, with nearly 25% of all cancers harbouring aberrations in one or more of these genes. A role for such aberrations in tumorigenesis is evidenced by cancer predisposition in both carriers of germline loss-of-function mutations and genetically engineered...

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Identifiers

PMID: 32303701
DOI: 10.1038/s41571-020-0357-3
PMCID: PMC8723792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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