Article
(mis)-Targeting of SWI/SNF complex(es) in cancer.
Cancer metastasis reviews - 1 Jun 2023
Reddy Divya, Bhattacharya Saikat, Workman Jerry L
Abstract excerpt
The ATP-dependent chromatin remodeling complex SWI/SNF (also called BAF) is critical for the regulation of gene expression. During the evolution from yeast to mammals, the BAF complex has evolved an enormous complexity that contains a high number of subunits encoded by various genes. Emerging studies highlight the frequent involvement of altered mammalian SWI/SNF chromatin-remodeling complexes in human cancers....
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