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Article

Effect of natural genetic variation on enhancer selection and function.

Nature - 28 Nov 2013

Heinz S, Romanoski C E, Benner C, Allison K A, Kaikkonen M U, Orozco L D, Glass C K

Abstract excerpt

The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of sequence variation on lineage-determining and signal-specific transcription factor binding, epigenomics and transcriptional outcomes in primary macrophages from...

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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24121437
DOI: 10.1038/nature12615
PMCID: PMC3994126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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