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Article

Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.

Cell - 4 Dec 2014

Gosselin David, Link Verena M, Romanoski Casey E, Fonseca Gregory J, Eichenfield Dawn Z, Spann Nathanael J, Stender Joshua D, Chun Hyun B, Garner Hannah, Geissmann Frederic, Glass Christopher K

Abstract excerpt

Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue macrophages also acquire context-specific functions that are important for normal tissue homeostasis. To investigate mechanisms responsible for tissue-specific functions, we analyzed the transcriptomes and enhancer landscapes of brain microglia and resident...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25480297
DOI: 10.1016/j.cell.2014.11.023
PMCID: PMC4364385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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